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Cat. No. Product Name Information
PC-62083

STIMA 1

p53 activator

STIMA 1 is a small molecule mutant p53 reactivator that can stimulate mutant p53 DNA binding in vitro, induces expression of p53 target proteins and triggers apoptosis in mutant p53-expressing human tumor cells..
PC-62082

CP-31398 dihydrochloride

p53 activator

CP-31398 (CP31398) dihydrochloride is a small molecule p53 reactivator that protects p53 from thermal denaturation, not only reactivates mutant p53 but also induces stabilization of wild type p53.
PC-62081

PK-7088

p53 Y220C reactivator

PK-7088 is a small molecule mutant p53 Y220C reactivator, promotes correct folding of Y220 mutant p53 and induces expression of p53 targets p21 and the Noxa, triggers nuclear export of the pro-apoptotic Bax protein to mitochondria..
PC-62020

RO 2443

Mdm2-MdmX inhibitor

RO 2443 is a potent, dual MDM2/MDMX antagonist that inhibits both MDM2 (IC50=33 nM) and MDMX (IC50=41 nM) binding to p53, but poor water solubility does not allow for a meaningful assessment of its cellular activity..
PC-61497

SLMP53-1

p53 reactivator

SLMP53-1 is a small molecule reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells.
PC-61496

DIMP53-1

p53-MDM2/X inhibitor

DIMP53-1 is a novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53, without effect on other MDM.
PC-61495

PK-11007

p53 activator

PK-11007 (PK11007) is a 2-sulfonylpyrimidine compound that is a mild thiol alkylator with anticancer activity toward p53-compromised cells, stabilizes p53 in vitro via selective alkylation.
PC-61494

COTI-2

p53 activator

COTI-2 (COTI2) is an orally available thiosemicarbazone that may act on mutant forms of p53 and PI3K/AKT/mTOR pathway.
PC-61324

HL001

Cyclophilin A inhibitor

HL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM, induces NSCLC cell cycle arrest and apoptosis via restoring p53 expression.
PC-60982

AM-7209

MDM2-p53 inhibitor

AM-7209 is a potent and selective inhibitor of the MDM2-p53 interaction with Kd of 38 pM, and IC50 of 1.6 nM.
PC-60481

DS-5272

MDM2-p53 inhibitor

DS-5272 is a potent and orally active p53-MDM2 interaction inhibitor with IC50 of 2.4 nM.
PC-60466

CTX-1

p53-HdmX inhibitor

A novel small molecule that overcomes HdmX-mediated p53 repression, binds directly to HdmX (Kd=450 nM) to prevent p53-HdmX complex formation.

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