| Cat. No. |
Product Name |
Information |
| PC-62020 |
RO 2443
Mdm2-MdmX inhibitor
|
RO 2443 is a potent, dual MDM2/MDMX antagonist that inhibits both MDM2 (IC50=33 nM) and MDMX (IC50=41 nM) binding to p53, but poor water solubility does not allow for a meaningful assessment of its cellular activity.. |
| PC-61497 |
SLMP53-1
p53 reactivator
|
SLMP53-1 is a small molecule reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells. |
| PC-61496 |
DIMP53-1
p53-MDM2/X inhibitor
|
DIMP53-1 is a novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53, without effect on other MDM. |
| PC-61495 |
PK-11007
p53 activator
|
PK-11007 (PK11007) is a 2-sulfonylpyrimidine compound that is a mild thiol alkylator with anticancer activity toward p53-compromised cells, stabilizes p53 in vitro via selective alkylation. |
| PC-61494 |
COTI-2
p53 activator
|
COTI-2 (COTI2) is an orally available thiosemicarbazone that may act on mutant forms of p53 and PI3K/AKT/mTOR pathway. |
| PC-61324 |
HL001
Cyclophilin A inhibitor
|
HL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM, induces NSCLC cell cycle arrest and apoptosis via restoring p53 expression. |
| PC-60982 |
AM-7209
MDM2-p53 inhibitor
|
AM-7209 is a potent and selective inhibitor of the MDM2-p53 interaction with Kd of 38 pM, and IC50 of 1.6 nM. |
| PC-60481 |
DS-5272
MDM2-p53 inhibitor
|
DS-5272 is a potent and orally active p53-MDM2 interaction inhibitor with IC50 of 2.4 nM. |
| PC-60466 |
CTX-1
p53-HdmX inhibitor
|
A novel small molecule that overcomes HdmX-mediated p53 repression, binds directly to HdmX (Kd=450 nM) to prevent p53-HdmX complex formation. |
| PC-60462 |
SP 141
MDM2 inhibitor
|
A novel specific MDM2 inhibitor that promotes MDM2 auto-ubiquitination and degradation. |
| PC-60443 |
RO-5963
Mdm2-MdmX inhibitor
|
RO-5963 is a potent, dual MDM2/MDMX-p53 interaction inhibitor with IC50 of 17 and 24 nM, respectively. |
| PC-60442 |
AM-8735
MDM2-p53 inhibitor
|
AM-8735 is a potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.4 nM), cellular potency (SJSA-1 EdU IC50=25 nM), and favorable pharmacokinetic properties. |
