| Cat. No. |
Product Name |
Information |
| PC-35095 |
ICEC 0942 hydrochloride
CDK7 inhibitor
|
ICEC 0942 (Samuraciclib, CT7001) hydrochloride is a potent, selective, orally active CDK7 inhibitor with IC50 of 41 nM, displays 15-fold selectivity over CDK2 (IC50=578 nM). |
| PC-43446 |
BS-181 hydrochloride
CDK7 inhibitor
|
BS-181 is a potent, selective CDK7 inhibitor with IC50 of 21 nM, 40-fold selectivity over CDK2/cycE and no significant activity against CDK1/cycB, CDK4/cycD1, CDK5/p35NCK, CDK6/cycD1, and CDK9/cycT (IC50>1 uM). |
| PC-43445 |
BS-181
CDK7 inhibitor
|
BS-181 is a potent, selective CDK7 inhibitor with IC50 of 21 nM, 40-fold selectivity over CDK2/cycE and no significant activity against CDK1/cycB, CDK4/cycD1, CDK5/p35NCK, CDK6/cycD1, and CDK9/cycT (IC50>1 uM). |
| PC-63464 |
JH-VIII-49
CDK8 inhibitor
|
JH-VIII-49 is a potent and selective inhibitor of CDK8 with IC50 of 16 nM, also inhibits CDK19 (IC50=8 nM). |
| PC-63455 |
FIT-039
CDK9 inhibitor
|
FIT-039 is a potent, selective CDK9 inhibitor with IC50 of 5.8 uM for CKD9/cyclin T1, suppresses the replication of HSV-1 (IC50=0.69 uM). |
| PC-63452 |
RO5454291
CDK5-p25 inhibitor
|
RO5258638 is a small molecule inhibitor of CDK5-p25 protein-protein interaction with IC50 of 1.39 uM.. |
| PC-63451 |
RO5258638
CDK5-p25 inhibitor
|
RO5258638 is a small molecule inhibitor of CDK5-p25 protein-protein interaction.. |
| PC-63305 |
HSD992
CDK2/3 inhibitor
|
HSD992 is a potent, selective CDK2/3 inhibitor with moderate CDK9 inhibition with IC50 of 18 nM, 57 nM and 49 nM for CDK3/cyclin E, CDK2/cyclin A1 and CDK2/cyclin E, respecively. |
| PC-63252 |
BI-1347
CDK8/CDK19 inhibitor
|
BI-1347 is a potent, selective inhibitor of CDK8/CDK19 with IC50 of 1.4 nM/1.9 nM, respectively. |
| PC-43411 |
CDK9-IN-1
CDK9 inhibitor
|
CDK9-IN-1 is a potent, selective CDK9 inhibitor with IC50 of 39 nM (CDK9/CycT1), >10-fold selectivity over CDK4 and >100-fold over CDK1/2/3/5/6/7, inhibits HIV-1 replication in cellular assays. |
| PC-43342 |
CDK9-IN-2
CDK9 inhibitor
|
CDK9-IN-2 (CDK9 inhibitor II) is a potent and selective CDK9 inhibitor with IC50 of <8 nM, example 4 in patent WO2011026917A1. |
| PC-43145 |
CCT251545
Wnt inhibitor, CDK8/19 inhibitor
|
CCT251545 is a potent, orally bioavailable inhibitor of Wnt signaling with IC50 of 5 nM, also is a potent and selective chemical probe for CDK8 and CDK19 with >100-fold selectivity over 291 other kinases. |
