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Cat. No. Product Name Information
PC-35095

ICEC 0942 hydrochloride

CDK7 inhibitor

ICEC 0942 (Samuraciclib, CT7001) hydrochloride is a potent, selective, orally active CDK7 inhibitor with IC50 of 41 nM, displays 15-fold selectivity over CDK2 (IC50=578 nM).
PC-43446

BS-181 hydrochloride

CDK7 inhibitor

BS-181 is a potent, selective CDK7 inhibitor with IC50 of 21 nM, 40-fold selectivity over CDK2/cycE and no significant activity against CDK1/cycB, CDK4/cycD1, CDK5/p35NCK, CDK6/cycD1, and CDK9/cycT (IC50>1 uM).
PC-43445

BS-181

CDK7 inhibitor

BS-181 is a potent, selective CDK7 inhibitor with IC50 of 21 nM, 40-fold selectivity over CDK2/cycE and no significant activity against CDK1/cycB, CDK4/cycD1, CDK5/p35NCK, CDK6/cycD1, and CDK9/cycT (IC50>1 uM).
PC-63464

JH-VIII-49

CDK8 inhibitor

JH-VIII-49 is a potent and selective inhibitor of CDK8 with IC50 of 16 nM, also inhibits CDK19 (IC50=8 nM).
PC-63455

FIT-039

CDK9 inhibitor

FIT-039 is a potent, selective CDK9 inhibitor with IC50 of 5.8 uM for CKD9/cyclin T1, suppresses the replication of HSV-1 (IC50=0.69 uM).
PC-63452

RO5454291

CDK5-p25 inhibitor

RO5258638 is a small molecule inhibitor of CDK5-p25 protein-protein interaction with IC50 of 1.39 uM..
PC-63451

RO5258638

CDK5-p25 inhibitor

RO5258638 is a small molecule inhibitor of CDK5-p25 protein-protein interaction..
PC-63305

HSD992

CDK2/3 inhibitor

HSD992 is a potent, selective CDK2/3 inhibitor with moderate CDK9 inhibition with IC50 of 18 nM, 57 nM and 49 nM for CDK3/cyclin E, CDK2/cyclin A1 and CDK2/cyclin E, respecively.
PC-63252

BI-1347

CDK8/CDK19 inhibitor

BI-1347 is a potent, selective inhibitor of CDK8/CDK19 with IC50 of 1.4 nM/1.9 nM, respectively.
PC-43411

CDK9-IN-1

CDK9 inhibitor

CDK9-IN-1 is a potent, selective CDK9 inhibitor with IC50 of 39 nM (CDK9/CycT1), >10-fold selectivity over CDK4 and >100-fold over CDK1/2/3/5/6/7, inhibits HIV-1 replication in cellular assays.
PC-43342

CDK9-IN-2

CDK9 inhibitor

CDK9-IN-2 (CDK9 inhibitor II) is a potent and selective CDK9 inhibitor with IC50 of <8 nM, example 4 in patent WO2011026917A1.
PC-43145

CCT251545

Wnt inhibitor, CDK8/19 inhibitor

CCT251545 is a potent, orally bioavailable inhibitor of Wnt signaling with IC50 of 5 nM, also is a potent and selective chemical probe for CDK8 and CDK19 with >100-fold selectivity over 291 other kinases.

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