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Cat. No. Product Name Information
PC-21457

K161

SHIP1/2 inhibitor

K161 is a potent, pan-SHIP1/2 inhibitor with IC50 of 1.5- 6 uM and 6.5-13 uM, respectively.
PC-21366

ATUX-1215

PP2A activator

ATUX-1215 is a direct, orally active small molecule activator of protein phosphatase 2A (PP2A), suppresses bleomycin-induced fibrosis in vivo.
PC-20969

Compound 182

PTP1B/PTPN2 inhibitor

Compound 182 is a highly potent and selective active site competitive inhibitor of PTP1B and PTPN2, inhibits the catalytic activities of PTP1B and PTPN2 with IC50 of 0.63 and 0.58 nM, respectively.
PC-20711

SBI-221

SHP2-E76K inhibitor

SBI-221 is a small molecule inhihitor of SHP2-E76K mutant with IC50 of 2.1 uM and 7.4 uM for SHP2-E76K and SHP2-WT in isothermal CETSA assays, respectively.
PC-20470

PTP1B inhibitor BDB

PTP1B inhibitor

PTP1B inhibitor BDB is a natural compound found in marine red algaea, is a selective, cell‐permeable and competitive inhibitor of PTP1B with IC50 of 1.86 uM.
PC-20469

PTP1B inhibitor BBR

PTP1B inhibitor

PTP1B inhibitor BBR is a selective, non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B with IC50 of 8 uM.
PC-20365

HN252

PPM1B inhibitor

HN252 is a potent protein phosphatase 1B (PPM1B) inhibitor with Ki of 0.52 uM and IC50 of 0.76 uM, shows no inhibition against topoisomerases in vitro.
PC-20341

PHPS1 sodium

SHP2 inhibitor

PHPS1 sodium is a potent, specific and cell-permeable inhibitor of protein tyrosine phosphatase Shp2 with Ki value of 0.73 uM.
PC-20340

PHPS1

SHP2 inhibitor

PHPS1 is a potent, specific and cell-permeable inhibitor of protein tyrosine phosphatase Shp2 with Ki value of 0.73 uM.
PC-20339

PTPN2 inhibitor 9

PTPN2 inhibitor

PTPN2 inhibitor 9 (PTP9) is small molecule inhibitor of protein tyrosine phosphatase non-receptor type 2 (PTPN2), sensitizes tumor cells to IFNγ treatment in vitro and to anti-PD-1 therapy in vivo.
PC-20250

JAB-3068

SHP2 inhibitor

JAB-3068 (JAB3068) is a potent, selective and orally bioavailable allosteric inhibitor of SHP2 with IC50 of 25.8 nM.
PC-20047

GDC-1971

SHP2 inhibitor

Migoprotafib (GDC-1971, RLY-1971) is a potent, selective, allosteric and orally bioavailable inhibitor of the non-receptor protein tyrosine phosphatase SHP2 (PTPN11), potently inhibits both wild-type SHP2 (IC50 <1 nM) and E76K activating mutant (IC50 < 250nM) in biochemical assays.

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