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Cat. No. Product Name Information
PC-24296

BRD6257

PPM1D inhibitor

BRD6257 is a potent, selective serine/threonine phosphatase PPM1D (Wip1, PP2Cδ) inhibitor with IC50 of 5 nM in LC-MS p38 MAPK assays.
PC-23059

ABBV-CLS-579

PTP1B/PTPN2 inhibitor

Tegeprotafib (ABBV-CLS-579) is a potent, selective orally active PTP1B/PTPN2 inhibitor with IC50 of 4.4 nM and 1-10 nM against PTPN2 and PTP1B, respectively
PC-22889

JAB-3312

SHP2 inhibitor

JAB-3312 is a potent, selective and allosteric SHP2 inhibitor with binding Kd of 0.37 nM and enzymatic IC50 of 1.9 nM.
PC-21980

SBI-0802767

LMPTP inhibitor

SBI-0802767 is a potent, selective low molecular weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 239 nM, remarkably selective over class I tyrosine-specific and dual-specific PTPs.
PC-21979

LMPTP inhibitor 6g

LMPTP inhibitor

LMPTP inhibitor 6g is a potent, selective, uncompetitive low molecular weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 83 nM, >1000-fold selective over other phosphatases.
PC-21978

LMPTP inhibitor 5d

LMPTP inhibitor

LMPTP inhibitor 5d is a potent, selective low molecular weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 20 nM, >1000-fold selective over other phosphatases.
PC-21977

LMPTP inhibitor 23 dihydrochloride

LMPTP inhibitor

LMPTP inhibitor 23 dihydrochloride is a potent, selective, orally bioavailable low-molecular-weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 0.8 uM.
PC-21976

Raphin1 acetate

PPP1R15B inhibitor

Raphin1 acetate (PPP1R15B inhibitor Raphin1) is a potent, selective, BBB-penetrant, orally bioavailable inhibitor of regulatory subunit of protein phosphatase 1, PPP1R15B, binds to the R15B-PP1c holophosphatase with Kd of 33 nM, 30-fold selective in binding R15B-PP1c over R15A-PP1c and does not bind to PP1c.
PC-21911

G6P6373

CLas STP inhibitor

G6P6373 is a specific Candidatus Liberibacter spp dual-specificity phosphatase (CLas STP) with binding KD of 24 uM, confers plant tolerance to Candidatus Liberibacter spp.
PC-21645

Voclosporin

Calcineurin inhibitor

Voclosporin (ISATX247, ISA247) is a small molecule calcineurin (Protein phosphatase-2B, PP2B) inhibitor, more potency than cyclosporine in vitro, substantially inhibits lymphocyte proliferation, T-cell activation and cytokine production.
PC-21457

K161

SHIP1/2 inhibitor

K161 is a potent, pan-SHIP1/2 inhibitor with IC50 of 1.5- 6 uM and 6.5-13 uM, respectively.
PC-21366

ATUX-1215

PP2A activator

ATUX-1215 is a direct, orally active small molecule activator of protein phosphatase 2A (PP2A), suppresses bleomycin-induced fibrosis in vivo.

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