| Cat. No. |
Product Name |
Information |
| PC-24296 |
BRD6257
PPM1D inhibitor
|
BRD6257 is a potent, selective serine/threonine phosphatase PPM1D (Wip1, PP2Cδ) inhibitor with IC50 of 5 nM in LC-MS p38 MAPK assays. |
| PC-23059 |
ABBV-CLS-579
PTP1B/PTPN2 inhibitor
|
Tegeprotafib (ABBV-CLS-579) is a potent, selective orally active PTP1B/PTPN2 inhibitor with IC50 of 4.4 nM and 1-10 nM against PTPN2 and PTP1B, respectively |
| PC-22889 |
JAB-3312
SHP2 inhibitor
|
Sitneprotafib (JAB-3312) is a potent, selective and allosteric SHP2 inhibitor with binding Kd of 0.37 nM and enzymatic IC50 of 1.9 nM. |
| PC-21980 |
SBI-0802767
LMPTP inhibitor
|
SBI-0802767 is a potent, selective low molecular weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 239 nM, remarkably selective over class I tyrosine-specific and dual-specific PTPs. |
| PC-21979 |
LMPTP inhibitor 6g
LMPTP inhibitor
|
LMPTP inhibitor 6g is a potent, selective, uncompetitive low molecular weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 83 nM, >1000-fold selective over other phosphatases. |
| PC-21978 |
LMPTP inhibitor 5d
LMPTP inhibitor
|
LMPTP inhibitor 5d is a potent, selective low molecular weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 20 nM, >1000-fold selective over other phosphatases. |
| PC-21977 |
LMPTP inhibitor 23 dihydrochloride
LMPTP inhibitor
|
LMPTP inhibitor 23 dihydrochloride is a potent, selective, orally bioavailable low-molecular-weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 0.8 uM. |
| PC-21976 |
Raphin1 acetate
PPP1R15B inhibitor
|
Raphin1 acetate (PPP1R15B inhibitor Raphin1) is a potent, selective, BBB-penetrant, orally bioavailable inhibitor of regulatory subunit of protein phosphatase 1, PPP1R15B, binds to the R15B-PP1c holophosphatase with Kd of 33 nM, 30-fold selective in binding R15B-PP1c over R15A-PP1c and does not bind to PP1c. |
| PC-21911 |
G6P6373
CLas STP inhibitor
|
G6P6373 is a specific Candidatus Liberibacter spp dual-specificity phosphatase (CLas STP) with binding KD of 24 uM, confers plant tolerance to Candidatus Liberibacter spp. |
| PC-21645 |
Voclosporin
Calcineurin inhibitor
|
Voclosporin (ISATX247, ISA247) is a small molecule calcineurin (Protein phosphatase-2B, PP2B) inhibitor, more potency than cyclosporine in vitro, substantially inhibits lymphocyte proliferation, T-cell activation and cytokine production. |
| PC-21457 |
K161
SHIP1/2 inhibitor
|
K161 is a potent, pan-SHIP1/2 inhibitor with IC50 of 1.5- 6 uM and 6.5-13 uM, respectively. |
| PC-21366 |
ATUX-1215
PP2A activator
|
ATUX-1215 is a direct, orally active small molecule activator of protein phosphatase 2A (PP2A), suppresses bleomycin-induced fibrosis in vivo. |
