| Cat. No. |
Product Name |
Information |
| PC-49676 |
BI 1015550
PDE4B inhibitor
|
BI 1015550 (Nerandomilast, VRN024219) is a potent, selective PDE4B inhibitor that preferentially inhibits hydrolysis of cAMP by PDE4B with IC50 of 10 nM, weakly inhibits PDE4A/4C/4D (IC50=248/8700/91 nM, respectively). |
| PC-49587 |
Orismilast
PDE4 inhibitor
|
Orismilast (LEO-32731) is a potent, selective, second generation PDE4 inhibitor with IC50 values of 3-52 nM for PDE4A/4B/4D subtype splice variants. |
| PC-47111 |
DSR-141562
PDE1 inhibitor
|
DSR-141562 (DSR141562) is a potent, selective orally available and brain-penetrant phosphodiesterase 1 (PDE1) inhibitor with IC50 of 97.6, 43.9 and 431.8 nM for human PDE1A, PDE1B and PDE1C, respectively. |
| PC-47068 |
TOP-N53
PDE5 inhibitor
|
TOP-N53 is a dual-acting nitric oxide (NO) donor and selective PDE5 inhibitor, potently inhibits PDE5 with IC50 of 1.6 nM. |
| PC-73314 |
BAY2666605
PDE3A-SLFN12 inducer
|
BAY2666605 is a potent, small molecule PDE3A-SLFN12 complex inducer with EC50 of 7 nM. |
| PC-73022 |
PDE4 activator MR-L2
PDE4 activator
|
PDE4 activator MR-L2 (MR-L2) is a small-molecule PDE4 activator, phenocopies PKA-mediated activation of long PDE4 isoforms. |
| PC-72598 |
BVQ1814
PDE10A inhibitor
|
BVQ1814 (BVQ-1814) is a highly effective fluorescent probe targeting PDE10A with highly potent affinity (IC50=0.9 nM), >1000-fold subfamily selectivity. |
| PC-72597 |
CPL500036
PDE10A inhibitor
|
CPL500036 (CPL-500036) is a highly potent, selective and orally bioavailable PDE10A inhibitor with IC50 of 35 nM. |
| PC-72100 |
AA6216
PDE4 inhibitor
|
AA6216 (AA 6216) is novel potent, selective PDE4 inhibitor with IC50 of 0.63 nM. |
| PC-35906 |
D159153
PDE4 inhibitor
|
D159153 (D-159153) is a novel potent, allosteric inhibitor of PDE4 with cellular IC50 of 28.5 and 6.6 nM for PDE4B1 and PDE4D3, respectively. |
| PC-35904 |
BPN14770
PDE4D inhibitor
|
Zatolmilast (BPN14770) is an allosteric inhibitor of phosphodiesterase 4D (PDE4D) with IC50 of 7.8 and 7.4 nM for human PDE4D7 and PDE4D3 respectively. |
| PC-35833 |
PF-04449613
PDE9 inhibitor
|
PF-04449613 (PF-9613, PF04449613, PF 04449613) is a potent and selective inhibitor of PDE9 with IC50 of 22 nM, >50-fold selective over PDE1C (IC50>1000 nM). |
