| Cat. No. |
Product Name |
Information |
| PC-24673 |
ISM5939
ENPP1 inhibitor
|
ISM5939 is a potent and selective, orally bioavailable ENPP1 inhibitor with IC50 of 0.63 nM against the 2,3-cGAMP degradation and 9.28 nM against ATP hydrolysis. |
| PC-23567 |
ENPP1 inhibitor VIR3
ENPP1 inhibitor
|
VIR3 is a potent, orally bioavailable Enpp1 with IC50 of <0.75 nM for ENPP1 cGAMP hydrolysis activity inhibition in in vitro assays. |
| PC-23482 |
BC11-38
PDE11 inhibitor
|
BC11-38 is a potent and selective PDE11 inhibitor with IC50 of 0.28 uM, without acitivity against PDE1-10. |
| PC-23191 |
PDE11A4 inhibitor 14b
PDE11A4 inhibitor
|
SMQ-03-20 (PDE11A4 inhibitor 14b) is a potent, selective, brain-penetrant PDE11A4 inhibitor with IC50 of 53 nM, cAMP EC50 of 4.3 uM. |
| PC-21517 |
PDE4B inhibitor A-33
PDE4B inhibitor
|
PDE4B inhibitor A-33 is a potent, selective inhibitor of PDE4B with IC50 of 15 nM, >100-fold selective over PDE4D. |
| PC-21464 |
ME3183
PDE4 inhibitor
|
ME3183 is a potent, selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 2.33, 1.28 and 1.63 nM for PDE4B1, PDE4A1A and PDE4D2 respectively. |
| PC-21326 |
ENPP1 inhibitor 29f
ENPP1 inhibitor
|
ENPP1 inhibitor 29f is a potent, orally active inhibitor of ecto-nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), inhibits the cGAMP hydrolysis by ENPP1 in vitro with IC50 of 68 nM. |
| PC-21325 |
MV-658
ENPP1 inhibitor
|
MV658 (ENPP-1-IN-1) is a potent small molecule ENPP1 inhibitor (IC50= 11 nM) as immune modulator.r. |
| PC-21270 |
PDE11A4 inhibitor 23b
PDE11A4 inhibitor
|
SMQ-02-57 (PDE11A4 inhibitor 23b) is a potent, selective PDE11A4 inhibitor with IC50 of 12 nM. |
| PC-20916 |
Sildenafil
PDE5 inhibitor
|
Sildenafil (UK-92480) is a potent, selective, orally active phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 3.9 nM. |
| PC-20681 |
Roflumilast
PDE4 inhibitor
|
Roflumilast (APTA-2217) is a potent, selective, orally active PDE4 inhibitor with IC50 of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively. |
| PC-20471 |
PDE4 inhibitor Compound A
PDE4B2 inhibitor
|
PDE4 inhibitor Compound A is a potent, highly selective PDE4 inhibitor with IC50 of 1.1 nM (PDE4B2), weakly inhibits PDE3 (IC50=150 nM) and does not inhibit other PDE subtypes. |
