| Cat. No. |
Product Name |
Information |
| PC-22344 |
CVN293
THIK-1 inhibitor
|
CVN293 (CVN-293) is a potent, selective and brain permeable potassium (K+) ion channel KCNK13 (THIK-1, K2P13.1) inhibitor with IC50 of 41 nM and 28 nM for human and mouse KCNK13, respectively. |
| PC-21733 |
VU0542270
Kir6.1/SUR2B inhibitor
|
VU0542270 is the first selective inhibitor of vascular Kir6.1/SUR2B KATP channel with IC50 of 129 nM, >300-fold selective over other members of the Kir channel family. |
| PC-20745 |
LAKI
TREK channel inhibitor
|
LAKI (Light Activated K+ channel Inhibitor) is a specific photoswitchable inhibitor of the pain-related two-pore-domain potassium (K2P) TREK and TRESK channels. |
| PC-20299 |
GIRK1/4 inhibitor 14b
GIRK1/4 inhibitor
|
GIRK1/4 inhibitor 14b is a potent, brain-sparing GIRK1/4 inhibitor with IC50 of 0.1 uM, exhibits excellent selectivity over GIRK1/2 channel. |
| PC-20298 |
NIP-142
Kv1.5 inhibitor
|
NIP-142 (NIP142) is an anti-arrhythmic agent by targeting cardiac K+ channel Kv1.5 (Kv1.5) currents, inhibits the steady-state phase with IC50 of 4.75 uM. |
| PC-49848 |
VU0546110
Sperm SLO3 channel inhibitor
|
VU0546110 (VU 0546110) is a potent, selective inhibitor of the sperm-specific potassium channel SLO3 with IC50 of 1.29 uM, impairs sperm function. |
| PC-49839 |
Retigabine
Kv7 opener
|
Retigabine (D-23129, XEN496) is an anticonvulsant compound and KV7 channel agonist (opener), enhances activation of KCNQ2/Q3 potassium channels. |
| PC-49797 |
ACOU001
Kv7.4 activator
|
ACOU001 (ACOU 001) is a potent small-molecule agonist of Kv7.4 (KCNQ4) channel with potential effect against ge-related hearing loss (ARHL) and other hearing impairments related to compromised KV7.4 function. |
| PC-49796 |
ACOU085
Kv7.4 activator
|
ACOU085 (ACOU 085) is a potent small-molecule agonist of Kv7.4 (KCNQ4) channel with higher potency than ML-213 in the nanomolar range. |
| PC-49538 |
SCR2682
Kv.7 activator
|
SCR2682 is a potent, selective neuronal voltage-gated potassium Kv7/KCNQ/M channel opener (activator) with EC50 of 9.8 nM (Kv7.2/Kv7.3), 100-fold more potency than retigabine. |
| PC-49468 |
TASK inhibitor F3
TASK Channel inhibitor
|
TASK inhibitor F3 is a potent, selective blocker of TWIK-related acid-sensitive K+ (TASK) channels with IC50 of 148 nM (TASK-1). |
| PC-49461 |
C101248
THIK-1 inhibitor
|
C101248 is the first selective small-molecule inhibitor of tandem pore domain halothane-inhibited K+ channel 1 (THIK-1) with IC50 of 50 nM for both mouse and human THIK-1. |
