| Cat. No. |
Product Name |
Information |
| PC-25675 |
JNJ-9350
Spermine oxidase inhibitor
|
JNJ-9350 is a potent, selective Spermine oxidase (SMOX) inhibitor with IC50 of 8 nM for human SMOX (hSMOX), shows remarkable selectivity over hPAOX (>89-fold). |
| PC-25660 |
B32B3
VprBP inhibitor
|
B32B3 is a specific, small‐molecule inhibitor of DCAF1 (Vpr-binding protein, VprBP) with IC50 of 0.6 uM, selectively inhibits H2AT120p with IC50 of 0.5 uM. |
| PC-25656 |
EPIC-1042
PTRF-CAV1 inhibitor
|
EPIC-1042 is a potent, small molecule PTRF/Cavin1-caveolin-1 interaction inhibitor with IC50 of 38 uM, inhibits the binding of PTRF to Caveolin-1 (CAV1), resulting in decreased secretion of small extracellular vesicles (sEVs). |
| PC-25644 |
ISR activator A8
RIG-I binder, ISR activator
|
ISR activator A8 is a specific small molecule activator of integrated stress response (ISR) through the binding of the cytosolic pattern recognition receptor RIG-I, subsequently activates the heme-regulated inhibitor (HRI) ISR kinase independent of an interferon response. |
| PC-25634 |
ZDHHC2 inhibitor TTZ1
zDHHC2 inhibitor
|
zDHHC2 inhibitor TTZ1 (Tetrazole-1, TTZ-1) is a specific enzymatic inhibitor of palmitoyltransferase ZDHHC2, inhibits human zDHHC2-mediated substrate (SNAP25) S-acylation in vitro with IC50 of 4.7 uM. |
| PC-25627 |
Vav1 inhibitor AB19
Vav1 inhibitor
|
Vav1 inhibitor AB19 is a small molecule inhibitor of guanine nucleotide exchange factor Vav1 atypical C1 domain (Vav1C1), effectly inhibits proliferation of Vav1-expressing cells, inhibits growth of patient-derived organoids models of pancreatic cancer. |
| PC-25516 |
iOXCT1
OXCT1 inhibitor
|
iOXCT1 (D574-0246) is a specific small molecule 3-Oxoacid CoA-transferase 1 (OXCT1) inhibitor, inhibits the dual enzymatic ketolytic and succinyltransferase activities of OXCT1 specifically. |
| PC-25504 |
DF-003
ALPK1 inhibitor
|
DF-003 (DF003) is a potent, selective and ATP-competitive alpha-kinase 1 (ALPK1) inhibitor with IC50 of 1.5 nM and 16 nM for human ALPK1 and ROSAH disease-causing mutant ALPK1[T237M] respectively. |
| PC-25479 |
SF-153
UHM splicing factor inhibitor
|
SF-153 is a small molecule inhibitor of UHM splicing factor RBM39 and SPF45 with IC50 of 45.8 uM for both, targets U2 Auxiliary Factor Homology Motif (UHM) domains, exerts anti-tumor activities in leukemia cell lines. |
| PC-25465 |
Greatwall inhibitor C-604
Greatwall inhibitor
|
Greatwall inhibitor C-604 (UOS-00054604) is a potent, highly selective Greatwall kinase (GWL, MASTL) inhibitor with IC50 of 9 nM in HTRF assays. |
| PC-25222 |
ASS1 inhibitor C-01
ASS1 inhibitor
|
ASS1 inhibitor C-01 is a small molecule inhibitor of argininosuccinate synthetase 1 (ASS1), binds to ASS1 directly with SPR Kd of 18.8 nM. |
| PC-25184 |
JX-078
LAT1 inhibitor
|
JX-078 is a potent, selective inhibitor of L-type amino acid transporters LAT1 (SLC7A5), inhibits [3H]-L-leucine uptake into HT-29 cells with IC50 of 121 nM, >10-fold selective over in LAT2. |
